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These include improved DNA repair (through PARP, another NAD+-dependent enzyme), enhanced autophagy (cellular cleanup), reduced inflammation, and mitochondrial quality control

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Without diet and exercise, any effect of the injection would be minimal

Important limitations on this safety profile: the longest trial was 24 weeks, the total trial population is small by modern standards, and the clinical trials used oral dosing

Indications: Used primarily to treat vitamin B12 deficiencies due to malabsorption, dietary inadequacies (e.g., in vegans), or certain medical conditions like pernicious anemia